o Symptoms Looked for
§ Overgrowth, asymmetry, and gigantism of the limbs
§ Increased size of an organ, or the body, or bones (hypertrophy)
§ Raised rough skin (verrucous epidermal naevi)
§ Deep lines and overgrowth of soft tissue on the soles of feet
§ Patches of overgrown blood or lymphatic vessels (vascular malformations)
§ Local overgrowth of fat (lipomas) or undergrowth of fat
§ Various tumors are more common in patients with Proteus syndrome but most are benign
§ Deep venous thromboses (blood clots) and the lodging of these blood clots in the lungs (this can be life threatening)
There is no age to when the disorder occurs. The genetic change or somatic event leading to this syndrome is likely to present shortly after conception and is propagated in one or more subsets of embryonic cells. Even so, the diagnosis may not be suspected in many individuals until later infancy or early childhood, depending on the degree of overgrowth or rate of cutaneous lesion appearance.
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